منابع مشابه
Glucose metabolism and pulsatile insulin release from isolated islets.
The effects of metabolic inhibition on insulin release and the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) were studied in individually perifused pancreatic islets from ob/ob mice. The modest basal secretion in the presence of 3 mmol/l glucose was pulsatile with a frequency of approximately 0.2/min, although [Ca(2+)](i) was stable at approximately 100 nmol/l. Introduction of 11 mmol/l glucos...
متن کاملSelf-powered glucose-responsive micropumps.
A self-powered polymeric micropump based on boronate chemistry is described. The pump is triggered by the presence of glucose in ambient conditions and induces convective fluid flows, with pumping velocity proportional to the glucose concentration. The pumping is due to buoyancy convection that originates from reaction-associated heat flux, as verified from experiments and finite difference mod...
متن کاملGlucose-induced pulsatile insulin release from single islets at stable and oscillatory cytoplasmic Ca21
Bergsten, Peter. Glucose-induced pulsatile insulin release from single islets at stable and oscillatory cytoplasmic Ca21. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E796– E800, 1998.—The cytoplasmic Ca21 concentration ([Ca]i) and insulin release were measured simultaneously in mouse pancreatic islets cultured overnight. [Ca]i was 105 nM and insulin release 3 pmol ·g21 ·s21 at 3 mM glucose. An...
متن کاملGlucose-induced pulsatile insulin release from single islets at stable and oscillatory cytoplasmic Ca2.
The cytoplasmic Ca2+ concentration ([Ca2+]i) and insulin release were measured simultaneously in mouse pancreatic islets cultured overnight. [Ca2+]iwas 105 nM and insulin release 3 pmol ⋅ g-1 ⋅ s-1at 3 mM glucose. An increase to 7 mM glucose reduced [Ca2+]itransiently, whereas insulin release doubled and was pulsatile with a frequency of 0.47 min-1. [Ca2+]i oscillations with similar frequency a...
متن کاملPulsatile Drug Delivery Release Technologies: an Overview
Pulsatile Drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, at the right time and in the right amount, as per the pathophysiological needs of the diseases, resulting in increasing patient compliance. Pulsatile Drug Delivery systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of ...
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ژورنال
عنوان ژورنال: Chemical Engineering Research and Design
سال: 2016
ISSN: 0263-8762
DOI: 10.1016/j.cherd.2015.11.024